top of page
실험

R&D

​R&D 
image.png

Present) YEPBIO R&D Center Director

- Medi-helpline_R&D Center Director

- Formerly employed at: K-MFDS, SK Chemical,
   Whan In Pharm., Korea Ginseng Corp

- Doctor of Pharmacy, Kyunghee University

- Technology Transfer Agent

COO  In-Ho, Jung

image.png

Present) YEPBIO Outside Director

Present) Professor, Sungkyunkwan University

Present) Adjunct Professor at Johns Hopkins

- Johns Hopkins University postdoctoral fellow

- University of Vienna, Ph.D.(Chemistry)

- Seoul National University College of Medicine,

   Master of Science (Tumor Biology)

CTO  Joo-Ho, Shin

CTO's Research Featured in Top-tier Scientific Journals

•  Cell. 2011 Mar 4;144(5):689-702 Ph.D Joo-Ho Shin

 PNAS. 2015 Sep 15;112(37):11696-701. Ph.D Joo-Ho Shin

•  Cell Rep. 2017 Jan 24;18(4):918-932.  Ph.D Joo-Ho Shin

•  Sci Transl med. 2021 Jul 28;13(604):eaax8891. Ph.D Joo-Ho Shin

•  Brain. 2021 Dec 31;144(12):3674-3691.  Ph.D Joo-Ho Shin

image.png
image.png
image.png
image.png
image.png

•  Parkin dysfunction causes PARIS accumulation in the substantia nigra

•  PARIS is a transcriptional repressor that inhibits PGC-1⍺, a mitochondrial regulator

•  PARIS accumulation causes dopaminergic neuron death

1. The first pioneering discovery of PARIS and Parkinson's disease

image.png

 PARIS(ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

image.png

This finding has led to a series of ongoing preclinical and clinical studies.

2.Our pipeline is supported by multiple follow-up studies.

• PARIS - PINK1 Relation 

그림3.png

• PARIS - c-Abl Relation 

image.png

• PARIS - NLRP3 Relation 

• PARIS - a-synuclein Relation 

image.png
image.png
image.png
image.png
image.png

Amid diverse causes lies a single convergence point : PARIS

'PARIS' inhibition = PD treatment

Artboard 24.png

​경기도 안양시 동안구 학의로 282 금강펜테리움IT타워 A동 1503호

282, Hagui-ro, Dongan-gu, Anyang-si, Gyeonggi-do, Republic of Korea 14056

Tel. 031-337-7191~2

Fax. 031-337-7193

Copyright © 2020 by YEP BIO Inc. All Rights Reserved.

bottom of page